Chromosomal instability and cancer: not just one CINgle mechanism
نویسندگان
چکیده
منابع مشابه
Chromosomal instability and human cancer.
Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell. A major question in cancer genetics is whether genetic instability is a c...
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The link between aneuploidy and cancer has been recognized over a century ago (1). Abnormalities in chromosome copy numbers arise from persistent errors in chromosome segregation during cell division, a process known as chromosomal instability (CIN) (2). CIN is a principal contributor to genetic heterogeneity in cancer (3) and is an important determinant of clinical prognosis and therapeutic re...
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ژورنال
عنوان ژورنال: Gut
سال: 2009
ISSN: 0017-5749
DOI: 10.1136/gut.2008.160143